> You process literal pounds of ADP to ATP and back to ADP, every day.
That's exactly my point. Some percentage of that ADP and ATP will be lost and the adenine/ribose broken down or reused for something else - cells are messy environments. Some of that will be lost permanently to waste. The more turnover in this process, the more opportunity for that loss.
If you eat fructose, you end up turning some of that into uric acid and excreting it, wastefully. It does other varied harm on its way out.