I'm not sure if that's true (considering just Hellenism and the descendants that Alexander the Great's people must have left between Thrace and India), but to address this more generally: of course if you don't have children you won't "genetically survive". The question was whether it would preclude you from great work. In this regard, Ancient Greece is an example of work that did survive - and even, for many centuries, served as a model.
I'm not sure if that's true (considering just Hellenism and the descendants that Alexander the Great's people must have left between Thrace and India), but to address this more generally: of course if you don't have children you won't "genetically survive". The question was whether it would preclude you from great work. In this regard, Ancient Greece is an example of work that did survive - and even, for many centuries, served as a model.