I hate noreply as well, at least as it relates to paying customers. At Hover, we switched to a policy of using help@hover.com for the default reply-to on all mailers and it works quite well. Zendesk and our mail system do a great job of filtering out the automated messages and bounce backs and a human being gets the rest. The remainder are usually full of opportunity for us. Consider this Startups - every time you use no reply, you are throwing away an opportunity to solidify a relationship with a customer or potential customer.