That sounds oddly curious to how psilocybin resistance works. With mushrooms, yo... | Hacker News

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		cameronh90 on Nov 24, 2020 \| parent \| context \| favorite \| on: Psilocybin and migraine: First of its kind trial r... That sounds oddly curious to how psilocybin resistance works. With mushrooms, you have to take the entire dose at the outset. As soon as you can feel it, you now have a strong resistance and any further dose will have a greatly diminished effect.

proverbialbunny on Nov 24, 2020 | [–]

Yep. It's a triptan, so closer to lsd, but same sort of premise.

smcleod on Nov 24, 2020 | [–]

I hear that's not the case for everyone ;)

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