If you don't care about dealing with the headaches of enterprise/corporate and know what you are getting into then sure. Not for me. I've tried multiple times after 15 years in various startups (and .edu). The kultur of a large company is a deal breaker. I'd suggest looking into consulting or , if you can do it, find a large company that needs 'SME' and 'Fixer' skills (if you have those). You can then approach work offsite or telework varying your vista on the basis of what project needs your skills. Defense contracting has a lot of this type of work.