If you enjoy these, you should also check out the videos from Startup Bootcamp on 9/11/2010 at MIT.

    Chris Wanstrath (Github)
    Mick Mountz (Kiva Systems)
    Ayr Muir (Clover Food Labs)
    George Bell (Excite)
    Bob Metcalfe (PARC, 3com, ethernet, etc.)
    Bill Clerico (WePay)
    James Lindenbaum (Heroku)
    Alexis Ohanian (Reddit and now YC ambassador)
    Stephen Wolfram (Wolfram Alpha and Mathematica)
    Kevin Hale (Wufoo)
    Ric Fulop (A123 Systems)
    David Cancel (Performable, Compete)

There are also more archived talks from previous years.

http://www.youtube.com/startupbootcamp