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My father is currently dying of malignant melanoma with brain metastasis...

I wish this treatment was available a few years ago.


My dad died 30 years ago after it spread to his liver. He was in the study at duke for what is today the standard treatment line for immunotherapy. I hope he was able to help. He died 9 months after his diagnosis.

Enjoy the time you have with him now and be grateful for all the years you've had. Nothing is going to make the loss of a parent "OK" and it will hurt no matter if you see it coming like you are or it's a surprise.

Remember to breathe.


Immune therapy didn't help? Darn.


Immune therapy is hit or miss. Friends lung cancer was exquisitely sensitive to it. Stage 4 to no sign of disease. Another friend with melanoma immune therapy didn't seem to help at all.

Melanoma is usually completely resistant to traditional cancer drugs. So that sometimes immune therapy works is very welcome.


Sadly it didn't. And it also lead to extreme bleeding in the brain metastasis that we had to stop it. Switched to BRAF/MEK inhibitors and that looked good for a few months until it didn't anymore.


That is devastating. How are you doing?


Coping. It's been a long process. When I saw his first diagnosis (he was diagnosed very late) I read the papers and knew that his chances are slim.

It's hard seeing him like this. 63 years old. Going from completely functioning to non-verbal in 3 months fucks you up


I'm so sorry to hear that, but thank you for sharing your story to highlight the importance of this!


Apparently this group was a bit late. Here is the first group with the same approach

https://www.nature.com/articles/s41586-026-10466-y


Get Uber drivers/taxis, truck drivers, ups/amazon delivery people etc. As your relay devices (and gives them extra cash for driving around)


For every train, there is a fixed number of tickets per price category. So sometimes, you can still find cheap tickets ("super sparpreis") a day before because thag specific train didn't have many bookings:)


Like a train ticket that spans the year break (depart December 31, arrive January 1).


Aw hell they picked up on that stupid American capitalist crap?

I worked in Germany in 2005 and back then everything was fixed price per kilometer for each train class, and you could get rail passes of sorts and get on whatever the hell trains you want during their validity. I'd take train roundtrips after work just to watch sunsets.


The price concept discussed above applies to long-distance trains. Local trains are still different, especially if you have the "Deutschlandticket" (germany ticket) you can just hop on any local train you like.


Dynamic pricing based on availability is much more efficient, which is a good thing.


I don't believe in "efficient" pricing being a good thing.

Railway systems with flat pricing and no stupid games are such a relief.


Okay then you need to accept some combination of higher average prices and sold out peak travel times.


> Aw hell they picked up on that stupid American capitalist crap?

Surge pricing is not an uniquely american concept.


The moment I started reading this, I got reminded of this recent study: https://arxiv.org/html/2503.10212v1

The scope is a bit different. The study uses an LLM to interpret pose estimation data and describe the behavior in each frame. The output is text which can be used to create embeddings of behavior. As someone who works in ethology, that's a clever (but maybe expensive) idea.

I think the author could use something similar. With multi-person pose estimation models.


Since its text, especially text with links to other articles, there is no need for tags.

If I had a clue how to do this (sorry, just a neuroscientist), I would probably create "communities" of pages on a network graph and weight the traversal across the graph network based on pages that the person liked (or spend X time on before).


This is protein on a western blot but the general idea is the same.


Streamrip on github


It depends.

40 out of 60 is easier to grasp for many people than 67%.

Percentages are better in cases where the numbers are harder to imagine (like your second example).


This is why I mentioned 2/3 - why keep a reductible fraction?


It's easy to misread as 40/60 (e.g. split)


Not "the Chinese subsidiaries". Only one of them.


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